A novel molecular scaffold has been synthesized, and its synthesis and incorporation into new analogues of biologically active molecules will be discussed. A comparison of the inhibitory activity of these compounds to the known type-2 diabetes compound (sitagliptin) against dipeptidyl peptidase-4 (DPP-4) will be shown.
Keywords: 1,2,4-triazole; Diabetes; crystal structure; dipeptyl peptidase VI (DPP-4) inhibitor; scaffold.